Homologous Recombination Repair Truncations Predict Hypermutation in Microsatellite Stable Colorectal and Endometrial Tumors

Somatic mutations in BRCA1/2 and other homologous recombination repair (HRR) genes have been associated with sensitivity to PARP inhibitors and/or platinum agents in several cancers, whereas hypermutant tumors caused by alterations in POLE or mismatch repair genes have demonstrated robust responses...

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Detalles Bibliográficos
Autores principales: Lee, Minyi, Eng, George, Barbari, Stephanie R., Deshpande, Vikram, Shcherbakova, Polina V., Gala, Manish K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145036/
https://www.ncbi.nlm.nih.gov/pubmed/32352724
http://dx.doi.org/10.14309/ctg.0000000000000149

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145036/
https://www.ncbi.nlm.nih.gov/pubmed/32352724
http://dx.doi.org/10.14309/ctg.0000000000000149

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