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Homologous Recombination Repair Truncations Predict Hypermutation in Microsatellite Stable Colorectal and Endometrial Tumors

Somatic mutations in BRCA1/2 and other homologous recombination repair (HRR) genes have been associated with sensitivity to PARP inhibitors and/or platinum agents in several cancers, whereas hypermutant tumors caused by alterations in POLE or mismatch repair genes have demonstrated robust responses...

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Detalles Bibliográficos
Autores principales:	Lee, Minyi, Eng, George, Barbari, Stephanie R., Deshpande, Vikram, Shcherbakova, Polina V., Gala, Manish K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Wolters Kluwer 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145036/ https://www.ncbi.nlm.nih.gov/pubmed/32352724 http://dx.doi.org/10.14309/ctg.0000000000000149

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