Application of optogenetic Amyloid-β distinguishes between metabolic and physical damages in neurodegeneration

The brains of Alzheimer’s disease patients show a decrease in brain mass and a preponderance of extracellular Amyloid-β plaques. These plaques are formed by aggregation of polypeptides that are derived from the Amyloid Precursor Protein (APP). Amyloid-β plaques are thought to play either a direct or...

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Detalles Bibliográficos
Autores principales: Lim, Chu Hsien, Kaur, Prameet, Teo, Emelyne, Lam, Vanessa Yuk Man, Zhu, Fangchen, Kibat, Caroline, Gruber, Jan, Mathuru, Ajay S, Tolwinski, Nicholas S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145416/
https://www.ncbi.nlm.nih.gov/pubmed/32228858
http://dx.doi.org/10.7554/eLife.52589

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145416/
https://www.ncbi.nlm.nih.gov/pubmed/32228858
http://dx.doi.org/10.7554/eLife.52589

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