Complementary roles of Pif1 helicase and single stranded DNA binding proteins in stimulating DNA replication through G-quadruplexes

G-quadruplexes (G4s) are stable secondary structures that can lead to the stalling of replication forks and cause genomic instability. Pif1 is a 5′ to 3′ helicase, localized to both the mitochondria and nucleus that can unwind G4s in vitro and prevent fork stalling at G4 forming sequences in vivo. U...

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Detalles Bibliográficos
Autores principales: Sparks, Melanie A, Singh, Saurabh P, Burgers, Peter M, Galletto, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145523/
https://www.ncbi.nlm.nih.gov/pubmed/31340040
http://dx.doi.org/10.1093/nar/gkz608

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145523/
https://www.ncbi.nlm.nih.gov/pubmed/31340040
http://dx.doi.org/10.1093/nar/gkz608

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