Sulfur-centered hemi-bond radicals as active intermediates in S-DNA phosphorothioate oxidation

Phosphorothioate (PS) modifications naturally appear in bacteria and archaea genome and are widely used as antisense strategy in gene therapy. But the chemical effects of PS introduction as a redox active site into DNA (S-DNA) is still poorly understood. Herein, we perform time-resolved spectroscopy...

Descripción completa

Detalles Bibliográficos
Autores principales: Jie, Jialong, Xia, Ye, Huang, Chun-Hua, Zhao, Hongmei, Yang, Chunfan, Liu, Kunhui, Song, Di, Zhu, Ben-Zhan, Su, Hongmei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145531/
https://www.ncbi.nlm.nih.gov/pubmed/31724721
http://dx.doi.org/10.1093/nar/gkz987

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145531/
https://www.ncbi.nlm.nih.gov/pubmed/31724721
http://dx.doi.org/10.1093/nar/gkz987

Ejemplares similares