Phylogenetic debugging of a complete human biosynthetic pathway transplanted into yeast

Cross-species pathway transplantation enables insight into a biological process not possible through traditional approaches. We replaced the enzymes catalyzing the entire Saccharomyces cerevisiae adenine de novo biosynthesis pathway with the human pathway. While the ‘humanized’ yeast grew in the abs...

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Detalles Bibliográficos
Autores principales: Agmon, Neta, Temple, Jasmine, Tang, Zuojian, Schraink, Tobias, Baron, Maayan, Chen, Jun, Mita, Paolo, Martin, James A, Tu, Benjamin P, Yanai, Itai, Fenyö, David, Boeke, Jef D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Synthetic Biology and Bioengineering
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145547/
https://www.ncbi.nlm.nih.gov/pubmed/31745563
http://dx.doi.org/10.1093/nar/gkz1098

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145547/
https://www.ncbi.nlm.nih.gov/pubmed/31745563
http://dx.doi.org/10.1093/nar/gkz1098

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