Phosphorylation orchestrates the structural ensemble of the intrinsically disordered protein HMGA1a and modulates its DNA binding to the NFκB promoter

High Mobility Group Protein A1a (HMGA1a) is a highly abundant nuclear protein, which plays a crucial role during embryogenesis, cell differentiation, and neoplasia. Here, we present the first ever NMR-based structural ensemble of full length HMGA1a. Our results show that the protein is not completel...

Descripción completa

Detalles Bibliográficos
Autores principales: Kohl, Bastian, Zhong, Xueyin, Herrmann, Christian, Stoll, Raphael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145567/
https://www.ncbi.nlm.nih.gov/pubmed/31340016
http://dx.doi.org/10.1093/nar/gkz614

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145567/
https://www.ncbi.nlm.nih.gov/pubmed/31340016
http://dx.doi.org/10.1093/nar/gkz614

Ejemplares similares