Atomic structures of the RNA end-healing 5′-OH kinase and 2′,3′-cyclic phosphodiesterase domains of fungal tRNA ligase: conformational switches in the kinase upon binding of the GTP phosphate donor

Fungal tRNA ligase (Trl1) rectifies RNA breaks with 2′,3′-cyclic-PO(4) and 5′-OH termini. Trl1 consists of three catalytic modules: an N-terminal ligase (LIG) domain; a central polynucleotide kinase (KIN) domain; and a C-terminal cyclic phosphodiesterase (CPD) domain. Trl1 enzymes found in all human...

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Detalles Bibliográficos
Autores principales: Banerjee, Ankan, Goldgur, Yehuda, Schwer, Beate, Shuman, Stewart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145591/
https://www.ncbi.nlm.nih.gov/pubmed/31722405
http://dx.doi.org/10.1093/nar/gkz1049

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145591/
https://www.ncbi.nlm.nih.gov/pubmed/31722405
http://dx.doi.org/10.1093/nar/gkz1049

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