Gene knockdown in malaria parasites via non-canonical RNAi

The lack of endogenous RNAi machinery in the malaria parasite Plasmodium hampers gene annotation and hence antimalarial drug and vaccine development. Here, we engineered rodent Plasmodium berghei to express a minimal, non-canonical RNAi machinery that solely requires Argonaute 2 (Ago2) and a modifie...

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Detalles Bibliográficos
Autores principales: Hentzschel, Franziska, Mitesser, Vera, Fraschka, Sabine Anne-Kristin, Krzikalla, Daria, Carrillo, Elena Herrera, Berkhout, Ben, Bártfai, Richárd, Mueller, Ann-Kristin, Grimm, Dirk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Methods Online
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145648/
https://www.ncbi.nlm.nih.gov/pubmed/31680162
http://dx.doi.org/10.1093/nar/gkz927

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145648/
https://www.ncbi.nlm.nih.gov/pubmed/31680162
http://dx.doi.org/10.1093/nar/gkz927

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