Crystal structure of the EcoKMcrA N-terminal domain (NEco): recognition of modified cytosine bases without flipping

EcoKMcrA from Escherichia coli restricts CpG methylated or hydroxymethylated DNA, and may act as a barrier against host DNA. The enzyme consists of a novel N-terminal specificity domain that we term NEco, and a C-terminal catalytic HNH domain. Here, we report that NEco and full-length EcoKMcrA speci...

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Detalles Bibliográficos
Autores principales: Slyvka, Anton, Zagorskaitė, Evelina, Czapinska, Honorata, Sasnauskas, Giedrius, Bochtler, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145662/
https://www.ncbi.nlm.nih.gov/pubmed/31724709
http://dx.doi.org/10.1093/nar/gkz1017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145662/
https://www.ncbi.nlm.nih.gov/pubmed/31724709
http://dx.doi.org/10.1093/nar/gkz1017

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