Inactivation of folylpolyglutamate synthetase Met7 results in genome instability driven by an increased dUTP/dTTP ratio

The accumulation of mutations is frequently associated with alterations in gene function leading to the onset of diseases, including cancer. Aiming to find novel genes that contribute to the stability of the genome, we screened the Saccharomyces cerevisiae deletion collection for increased mutator p...

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Detalles Bibliográficos
Autores principales: Schmidt, Tobias T, Sharma, Sushma, Reyes, Gloria X, Kolodziejczak, Anna, Wagner, Tina, Luke, Brian, Hofer, Anders, Chabes, Andrei, Hombauer, Hans
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145683/
https://www.ncbi.nlm.nih.gov/pubmed/31647103
http://dx.doi.org/10.1093/nar/gkz1006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145683/
https://www.ncbi.nlm.nih.gov/pubmed/31647103
http://dx.doi.org/10.1093/nar/gkz1006

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