TGFβ suppresses CD8(+) T cell expression of CXCR3 and tumor trafficking

Transforming growth factor beta (TGFβ) is a multipotent immunosuppressive cytokine. TGFβ excludes immune cells from tumors, and TGFβ inhibition improves the efficacy of cytotoxic and immune therapies. Using preclinical colorectal cancer models in cell type-conditional TGFβ receptor I (ALK5) knockout...

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Detalles Bibliográficos
Autores principales: Gunderson, Andrew J., Yamazaki, Tomoko, McCarty, Kayla, Fox, Nathaniel, Phillips, Michaela, Alice, Alejandro, Blair, Tiffany, Whiteford, Mark, O’Brien, David, Ahmad, Rehan, Kiely, Maria X., Hayman, Amanda, Crocenzi, Todd, Gough, Michael J., Crittenden, Marka R., Young, Kristina H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145847/
https://www.ncbi.nlm.nih.gov/pubmed/32273499
http://dx.doi.org/10.1038/s41467-020-15404-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145847/
https://www.ncbi.nlm.nih.gov/pubmed/32273499
http://dx.doi.org/10.1038/s41467-020-15404-8

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