Differential kinase activity of ACVR1 G328V and R206H mutations with implications to possible TβRI cross-talk in diffuse intrinsic pontine glioma

Diffuse intrinsic pontine glioma (DIPG) is a lethal pediatric brain cancer whose median survival time is under one year. The possible roles of the two most common DIPG associated cytoplasmic ACVR1 receptor kinase domain mutants, G328V and R206H, are reexamined in the context of new biochemical resul...

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Detalles Bibliográficos
Autores principales: Cao, Hongnan, Jin, Miao, Gao, Mu, Zhou, Hongyi, Tao, Yizhi Jane, Skolnick, Jeffrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145857/
https://www.ncbi.nlm.nih.gov/pubmed/32273545
http://dx.doi.org/10.1038/s41598-020-63061-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145857/
https://www.ncbi.nlm.nih.gov/pubmed/32273545
http://dx.doi.org/10.1038/s41598-020-63061-0

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