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A Suboptimal Diet Is Associated with Poorer Cognition: The NUDAD Project
Nutrition is one of the modifiable risk factors for cognitive decline and Alzheimer’s disease (AD) dementia, and is therefore highly relevant in the context of prevention. However, knowledge of dietary quality in clinical populations on the spectrum of AD dementia is lacking, therefore we studied th...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7146357/ https://www.ncbi.nlm.nih.gov/pubmed/32155876 http://dx.doi.org/10.3390/nu12030703 |
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author | Fieldhouse, Jay L. P. Doorduijn, Astrid S. de Leeuw, Francisca A. Verhaar, Barbara J. H. Koene, Ted Wesselman, Linda M. P. de van der Schueren, Marian A.E. Visser, Marjolein van de Rest, Ondine Scheltens, Philip Kester, Maartje I. van der Flier, Wiesje M. |
author_facet | Fieldhouse, Jay L. P. Doorduijn, Astrid S. de Leeuw, Francisca A. Verhaar, Barbara J. H. Koene, Ted Wesselman, Linda M. P. de van der Schueren, Marian A.E. Visser, Marjolein van de Rest, Ondine Scheltens, Philip Kester, Maartje I. van der Flier, Wiesje M. |
author_sort | Fieldhouse, Jay L. P. |
collection | PubMed |
description | Nutrition is one of the modifiable risk factors for cognitive decline and Alzheimer’s disease (AD) dementia, and is therefore highly relevant in the context of prevention. However, knowledge of dietary quality in clinical populations on the spectrum of AD dementia is lacking, therefore we studied the association between dietary quality and cognitive impairment in Alzheimer’s disease (AD) dementia, mild cognitive impairment (MCI) and controls. We included 357 participants from the NUDAD project (134 AD dementia, 90 MCI, 133 controls). We assessed adherence to dietary guidelines (components: vegetables, fruit, fibers, fish, saturated fat, trans-fat, salt, and alcohol), and cognitive performance (domains: memory, language, visuospatial functioning, attention, and executive functioning). In the total population, linear regression analyses showed a lower vegetable intake is associated with poorer global cognition, visuospatial functioning, attention and executive functioning. In AD dementia, lower total adherence to dietary guidelines and higher alcohol intake were associated with poorer memory, a lower vegetable intake with poorer global cognition and executive functioning, and a higher trans-fat intake with poorer executive functioning. In conclusion, a suboptimal diet is associated with more severely impaired cognition—this association is mostly attributable to a lower vegetable intake and is most pronounced in AD dementia. |
format | Online Article Text |
id | pubmed-7146357 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-71463572020-04-15 A Suboptimal Diet Is Associated with Poorer Cognition: The NUDAD Project Fieldhouse, Jay L. P. Doorduijn, Astrid S. de Leeuw, Francisca A. Verhaar, Barbara J. H. Koene, Ted Wesselman, Linda M. P. de van der Schueren, Marian A.E. Visser, Marjolein van de Rest, Ondine Scheltens, Philip Kester, Maartje I. van der Flier, Wiesje M. Nutrients Article Nutrition is one of the modifiable risk factors for cognitive decline and Alzheimer’s disease (AD) dementia, and is therefore highly relevant in the context of prevention. However, knowledge of dietary quality in clinical populations on the spectrum of AD dementia is lacking, therefore we studied the association between dietary quality and cognitive impairment in Alzheimer’s disease (AD) dementia, mild cognitive impairment (MCI) and controls. We included 357 participants from the NUDAD project (134 AD dementia, 90 MCI, 133 controls). We assessed adherence to dietary guidelines (components: vegetables, fruit, fibers, fish, saturated fat, trans-fat, salt, and alcohol), and cognitive performance (domains: memory, language, visuospatial functioning, attention, and executive functioning). In the total population, linear regression analyses showed a lower vegetable intake is associated with poorer global cognition, visuospatial functioning, attention and executive functioning. In AD dementia, lower total adherence to dietary guidelines and higher alcohol intake were associated with poorer memory, a lower vegetable intake with poorer global cognition and executive functioning, and a higher trans-fat intake with poorer executive functioning. In conclusion, a suboptimal diet is associated with more severely impaired cognition—this association is mostly attributable to a lower vegetable intake and is most pronounced in AD dementia. MDPI 2020-03-06 /pmc/articles/PMC7146357/ /pubmed/32155876 http://dx.doi.org/10.3390/nu12030703 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Fieldhouse, Jay L. P. Doorduijn, Astrid S. de Leeuw, Francisca A. Verhaar, Barbara J. H. Koene, Ted Wesselman, Linda M. P. de van der Schueren, Marian A.E. Visser, Marjolein van de Rest, Ondine Scheltens, Philip Kester, Maartje I. van der Flier, Wiesje M. A Suboptimal Diet Is Associated with Poorer Cognition: The NUDAD Project |
title | A Suboptimal Diet Is Associated with Poorer Cognition: The NUDAD Project |
title_full | A Suboptimal Diet Is Associated with Poorer Cognition: The NUDAD Project |
title_fullStr | A Suboptimal Diet Is Associated with Poorer Cognition: The NUDAD Project |
title_full_unstemmed | A Suboptimal Diet Is Associated with Poorer Cognition: The NUDAD Project |
title_short | A Suboptimal Diet Is Associated with Poorer Cognition: The NUDAD Project |
title_sort | suboptimal diet is associated with poorer cognition: the nudad project |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7146357/ https://www.ncbi.nlm.nih.gov/pubmed/32155876 http://dx.doi.org/10.3390/nu12030703 |
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