Cargando…

A Suboptimal Diet Is Associated with Poorer Cognition: The NUDAD Project

Nutrition is one of the modifiable risk factors for cognitive decline and Alzheimer’s disease (AD) dementia, and is therefore highly relevant in the context of prevention. However, knowledge of dietary quality in clinical populations on the spectrum of AD dementia is lacking, therefore we studied th...

Descripción completa

Detalles Bibliográficos
Autores principales: Fieldhouse, Jay L. P., Doorduijn, Astrid S., de Leeuw, Francisca A., Verhaar, Barbara J. H., Koene, Ted, Wesselman, Linda M. P., de van der Schueren, Marian A.E., Visser, Marjolein, van de Rest, Ondine, Scheltens, Philip, Kester, Maartje I., van der Flier, Wiesje M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7146357/
https://www.ncbi.nlm.nih.gov/pubmed/32155876
http://dx.doi.org/10.3390/nu12030703
_version_ 1783520182516318208
author Fieldhouse, Jay L. P.
Doorduijn, Astrid S.
de Leeuw, Francisca A.
Verhaar, Barbara J. H.
Koene, Ted
Wesselman, Linda M. P.
de van der Schueren, Marian A.E.
Visser, Marjolein
van de Rest, Ondine
Scheltens, Philip
Kester, Maartje I.
van der Flier, Wiesje M.
author_facet Fieldhouse, Jay L. P.
Doorduijn, Astrid S.
de Leeuw, Francisca A.
Verhaar, Barbara J. H.
Koene, Ted
Wesselman, Linda M. P.
de van der Schueren, Marian A.E.
Visser, Marjolein
van de Rest, Ondine
Scheltens, Philip
Kester, Maartje I.
van der Flier, Wiesje M.
author_sort Fieldhouse, Jay L. P.
collection PubMed
description Nutrition is one of the modifiable risk factors for cognitive decline and Alzheimer’s disease (AD) dementia, and is therefore highly relevant in the context of prevention. However, knowledge of dietary quality in clinical populations on the spectrum of AD dementia is lacking, therefore we studied the association between dietary quality and cognitive impairment in Alzheimer’s disease (AD) dementia, mild cognitive impairment (MCI) and controls. We included 357 participants from the NUDAD project (134 AD dementia, 90 MCI, 133 controls). We assessed adherence to dietary guidelines (components: vegetables, fruit, fibers, fish, saturated fat, trans-fat, salt, and alcohol), and cognitive performance (domains: memory, language, visuospatial functioning, attention, and executive functioning). In the total population, linear regression analyses showed a lower vegetable intake is associated with poorer global cognition, visuospatial functioning, attention and executive functioning. In AD dementia, lower total adherence to dietary guidelines and higher alcohol intake were associated with poorer memory, a lower vegetable intake with poorer global cognition and executive functioning, and a higher trans-fat intake with poorer executive functioning. In conclusion, a suboptimal diet is associated with more severely impaired cognition—this association is mostly attributable to a lower vegetable intake and is most pronounced in AD dementia.
format Online
Article
Text
id pubmed-7146357
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-71463572020-04-15 A Suboptimal Diet Is Associated with Poorer Cognition: The NUDAD Project Fieldhouse, Jay L. P. Doorduijn, Astrid S. de Leeuw, Francisca A. Verhaar, Barbara J. H. Koene, Ted Wesselman, Linda M. P. de van der Schueren, Marian A.E. Visser, Marjolein van de Rest, Ondine Scheltens, Philip Kester, Maartje I. van der Flier, Wiesje M. Nutrients Article Nutrition is one of the modifiable risk factors for cognitive decline and Alzheimer’s disease (AD) dementia, and is therefore highly relevant in the context of prevention. However, knowledge of dietary quality in clinical populations on the spectrum of AD dementia is lacking, therefore we studied the association between dietary quality and cognitive impairment in Alzheimer’s disease (AD) dementia, mild cognitive impairment (MCI) and controls. We included 357 participants from the NUDAD project (134 AD dementia, 90 MCI, 133 controls). We assessed adherence to dietary guidelines (components: vegetables, fruit, fibers, fish, saturated fat, trans-fat, salt, and alcohol), and cognitive performance (domains: memory, language, visuospatial functioning, attention, and executive functioning). In the total population, linear regression analyses showed a lower vegetable intake is associated with poorer global cognition, visuospatial functioning, attention and executive functioning. In AD dementia, lower total adherence to dietary guidelines and higher alcohol intake were associated with poorer memory, a lower vegetable intake with poorer global cognition and executive functioning, and a higher trans-fat intake with poorer executive functioning. In conclusion, a suboptimal diet is associated with more severely impaired cognition—this association is mostly attributable to a lower vegetable intake and is most pronounced in AD dementia. MDPI 2020-03-06 /pmc/articles/PMC7146357/ /pubmed/32155876 http://dx.doi.org/10.3390/nu12030703 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Fieldhouse, Jay L. P.
Doorduijn, Astrid S.
de Leeuw, Francisca A.
Verhaar, Barbara J. H.
Koene, Ted
Wesselman, Linda M. P.
de van der Schueren, Marian A.E.
Visser, Marjolein
van de Rest, Ondine
Scheltens, Philip
Kester, Maartje I.
van der Flier, Wiesje M.
A Suboptimal Diet Is Associated with Poorer Cognition: The NUDAD Project
title A Suboptimal Diet Is Associated with Poorer Cognition: The NUDAD Project
title_full A Suboptimal Diet Is Associated with Poorer Cognition: The NUDAD Project
title_fullStr A Suboptimal Diet Is Associated with Poorer Cognition: The NUDAD Project
title_full_unstemmed A Suboptimal Diet Is Associated with Poorer Cognition: The NUDAD Project
title_short A Suboptimal Diet Is Associated with Poorer Cognition: The NUDAD Project
title_sort suboptimal diet is associated with poorer cognition: the nudad project
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7146357/
https://www.ncbi.nlm.nih.gov/pubmed/32155876
http://dx.doi.org/10.3390/nu12030703
work_keys_str_mv AT fieldhousejaylp asuboptimaldietisassociatedwithpoorercognitionthenudadproject
AT doorduijnastrids asuboptimaldietisassociatedwithpoorercognitionthenudadproject
AT deleeuwfranciscaa asuboptimaldietisassociatedwithpoorercognitionthenudadproject
AT verhaarbarbarajh asuboptimaldietisassociatedwithpoorercognitionthenudadproject
AT koeneted asuboptimaldietisassociatedwithpoorercognitionthenudadproject
AT wesselmanlindamp asuboptimaldietisassociatedwithpoorercognitionthenudadproject
AT devanderschuerenmarianae asuboptimaldietisassociatedwithpoorercognitionthenudadproject
AT vissermarjolein asuboptimaldietisassociatedwithpoorercognitionthenudadproject
AT vanderestondine asuboptimaldietisassociatedwithpoorercognitionthenudadproject
AT scheltensphilip asuboptimaldietisassociatedwithpoorercognitionthenudadproject
AT kestermaartjei asuboptimaldietisassociatedwithpoorercognitionthenudadproject
AT vanderflierwiesjem asuboptimaldietisassociatedwithpoorercognitionthenudadproject
AT fieldhousejaylp suboptimaldietisassociatedwithpoorercognitionthenudadproject
AT doorduijnastrids suboptimaldietisassociatedwithpoorercognitionthenudadproject
AT deleeuwfranciscaa suboptimaldietisassociatedwithpoorercognitionthenudadproject
AT verhaarbarbarajh suboptimaldietisassociatedwithpoorercognitionthenudadproject
AT koeneted suboptimaldietisassociatedwithpoorercognitionthenudadproject
AT wesselmanlindamp suboptimaldietisassociatedwithpoorercognitionthenudadproject
AT devanderschuerenmarianae suboptimaldietisassociatedwithpoorercognitionthenudadproject
AT vissermarjolein suboptimaldietisassociatedwithpoorercognitionthenudadproject
AT vanderestondine suboptimaldietisassociatedwithpoorercognitionthenudadproject
AT scheltensphilip suboptimaldietisassociatedwithpoorercognitionthenudadproject
AT kestermaartjei suboptimaldietisassociatedwithpoorercognitionthenudadproject
AT vanderflierwiesjem suboptimaldietisassociatedwithpoorercognitionthenudadproject