Synthesis and Antimicrobial Properties of a Ciprofloxacin and PAMAM-dendrimer Conjugate

Infections caused by bacteria resistant to antibiotics are an increasing problem. Multivalent antibiotics could be a solution. In the present study, a covalent conjugate between Ciprofloxacin and a G0-PAMAM dendrimer has been synthesized and tested against clinically relevant Gram-positive and Gram-...

Descripción completa

Detalles Bibliográficos
Autores principales: Svenningsen, Søren Wedel, Frederiksen, Rikki Franklin, Counil, Claire, Ficker, Mario, Leisner, Jørgen J., Christensen, Jørn Bolstad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7146445/
https://www.ncbi.nlm.nih.gov/pubmed/32197523
http://dx.doi.org/10.3390/molecules25061389
_version_ 1783520204415827968
author Svenningsen, Søren Wedel
Frederiksen, Rikki Franklin
Counil, Claire
Ficker, Mario
Leisner, Jørgen J.
Christensen, Jørn Bolstad
author_facet Svenningsen, Søren Wedel
Frederiksen, Rikki Franklin
Counil, Claire
Ficker, Mario
Leisner, Jørgen J.
Christensen, Jørn Bolstad
author_sort Svenningsen, Søren Wedel
collection PubMed
description Infections caused by bacteria resistant to antibiotics are an increasing problem. Multivalent antibiotics could be a solution. In the present study, a covalent conjugate between Ciprofloxacin and a G0-PAMAM dendrimer has been synthesized and tested against clinically relevant Gram-positive and Gram-negative bacteria. The conjugate has antimicrobial activity and there is a positive dendritic effect compared to Ciprofloxacin itself.
format Online
Article
Text
id pubmed-7146445
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-71464452020-04-15 Synthesis and Antimicrobial Properties of a Ciprofloxacin and PAMAM-dendrimer Conjugate Svenningsen, Søren Wedel Frederiksen, Rikki Franklin Counil, Claire Ficker, Mario Leisner, Jørgen J. Christensen, Jørn Bolstad Molecules Article Infections caused by bacteria resistant to antibiotics are an increasing problem. Multivalent antibiotics could be a solution. In the present study, a covalent conjugate between Ciprofloxacin and a G0-PAMAM dendrimer has been synthesized and tested against clinically relevant Gram-positive and Gram-negative bacteria. The conjugate has antimicrobial activity and there is a positive dendritic effect compared to Ciprofloxacin itself. MDPI 2020-03-18 /pmc/articles/PMC7146445/ /pubmed/32197523 http://dx.doi.org/10.3390/molecules25061389 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Svenningsen, Søren Wedel
Frederiksen, Rikki Franklin
Counil, Claire
Ficker, Mario
Leisner, Jørgen J.
Christensen, Jørn Bolstad
Synthesis and Antimicrobial Properties of a Ciprofloxacin and PAMAM-dendrimer Conjugate
title Synthesis and Antimicrobial Properties of a Ciprofloxacin and PAMAM-dendrimer Conjugate
title_full Synthesis and Antimicrobial Properties of a Ciprofloxacin and PAMAM-dendrimer Conjugate
title_fullStr Synthesis and Antimicrobial Properties of a Ciprofloxacin and PAMAM-dendrimer Conjugate
title_full_unstemmed Synthesis and Antimicrobial Properties of a Ciprofloxacin and PAMAM-dendrimer Conjugate
title_short Synthesis and Antimicrobial Properties of a Ciprofloxacin and PAMAM-dendrimer Conjugate
title_sort synthesis and antimicrobial properties of a ciprofloxacin and pamam-dendrimer conjugate
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7146445/
https://www.ncbi.nlm.nih.gov/pubmed/32197523
http://dx.doi.org/10.3390/molecules25061389
work_keys_str_mv AT svenningsensørenwedel synthesisandantimicrobialpropertiesofaciprofloxacinandpamamdendrimerconjugate
AT frederiksenrikkifranklin synthesisandantimicrobialpropertiesofaciprofloxacinandpamamdendrimerconjugate
AT counilclaire synthesisandantimicrobialpropertiesofaciprofloxacinandpamamdendrimerconjugate
AT fickermario synthesisandantimicrobialpropertiesofaciprofloxacinandpamamdendrimerconjugate
AT leisnerjørgenj synthesisandantimicrobialpropertiesofaciprofloxacinandpamamdendrimerconjugate
AT christensenjørnbolstad synthesisandantimicrobialpropertiesofaciprofloxacinandpamamdendrimerconjugate

Ejemplares similares