Neuronal BIN1 Regulates Presynaptic Neurotransmitter Release and Memory Consolidation

BIN1, a member of the BAR adaptor protein family, is a significant late-onset Alzheimer disease risk factor. Here, we investigate BIN1 function in the brain using conditional knockout (cKO) models. Loss of neuronal Bin1 expression results in the select impairment of spatial learning and memory. Exam...

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Detalles Bibliográficos
Autores principales: De Rossi, Pierre, Nomura, Toshihiro, Andrew, Robert J., Masse, Nicolas Y., Sampathkumar, Vandana, Musial, Timothy F., Sudwarts, Ari, Recupero, Aleksandra J., Le Metayer, Thomas, Hansen, Mitchell T., Shim, Ha-Na, Krause, Sofia V., Freedman, David J., Bindokas, Vytas P., Kasthuri, Narayanan, Nicholson, Daniel A., Contractor, Anis, Thinakaran, Gopal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7146643/
https://www.ncbi.nlm.nih.gov/pubmed/32160554
http://dx.doi.org/10.1016/j.celrep.2020.02.026

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7146643/
https://www.ncbi.nlm.nih.gov/pubmed/32160554
http://dx.doi.org/10.1016/j.celrep.2020.02.026

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