Structure-Guided Design and In-Cell Target Profiling of a Cell-Active Target Engagement Probe for PARP Inhibitors

[Image: see text] Inhibition of the poly(ADP-ribose) polymerase (PARP) family of enzymes has become an attractive therapeutic strategy in oncology and beyond; however, chemical tools to profile PARP engagement in live cells are lacking. Herein, we report the design and application of PARPYnD, the fi...

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Detalles Bibliográficos
Autores principales: Howard, Ryan T., Hemsley, Paul, Petteruti, Philip, Saunders, Charlie N., Molina Bermejo, Javier A., Scott, James S., Johannes, Jeffrey W., Tate, Edward W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7146755/
https://www.ncbi.nlm.nih.gov/pubmed/32017532
http://dx.doi.org/10.1021/acschembio.9b00963

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7146755/
https://www.ncbi.nlm.nih.gov/pubmed/32017532
http://dx.doi.org/10.1021/acschembio.9b00963

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