A Dinuclear Ruthenium(II) Complex Excited by Near-Infrared Light through Two-Photon Absorption Induces Phototoxicity Deep within Hypoxic Regions of Melanoma Cancer Spheroids

[Image: see text] The dinuclear photo-oxidizing Ru(II) complex [{Ru(TAP(2))}(2)(tpphz)](4+) (TAP = 1,4,5,8- tetraazaphenanthrene, tpphz = tetrapyrido[3,2-a:2′,3′-c:3″,2′′-h:2‴,3′′′-j]phenazine), 1(4+), is readily taken up by live cells localizing in mitochondria and nuclei. In this study, the two-ph...

Descripción completa

Detalles Bibliográficos
Autores principales: Raza, Ahtasham, Archer, Stuart A., Fairbanks, Simon D., Smitten, Kirsty L., Botchway, Stanley W., Thomas, James A., MacNeil, Sheila, Haycock, John W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7146853/
https://www.ncbi.nlm.nih.gov/pubmed/32065521
http://dx.doi.org/10.1021/jacs.9b11313

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7146853/
https://www.ncbi.nlm.nih.gov/pubmed/32065521
http://dx.doi.org/10.1021/jacs.9b11313

Ejemplares similares