Oocytes mount a noncanonical DNA damage response involving APC-Cdh1–mediated proteolysis

In mitotic cells, DNA damage induces temporary G2 arrest via inhibitory Cdk1 phosphorylation. In contrast, fully grown G2-stage oocytes readily enter M phase immediately following chemical induction of DNA damage in vitro, indicating that the canonical immediate-response G2/M DNA damage response (DD...

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Detalles Bibliográficos
Autores principales: Subramanian, Goutham Narayanan, Greaney, Jessica, Wei, Zhe, Becherel, Olivier, Lavin, Martin, Homer, Hayden Anthony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7147104/
https://www.ncbi.nlm.nih.gov/pubmed/32328643
http://dx.doi.org/10.1083/jcb.201907213

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7147104/
https://www.ncbi.nlm.nih.gov/pubmed/32328643
http://dx.doi.org/10.1083/jcb.201907213

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