Chromosomes function as a barrier to mitotic spindle bipolarity in polyploid cells

Ploidy variations such as genome doubling are frequent in human tumors and have been associated with genetic instability favoring tumor progression. How polyploid cells deal with increased centrosome numbers and DNA content remains unknown. Using Drosophila neuroblasts and human cancer cells to stud...

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Detalles Bibliográficos
Autores principales: Goupil, Alix, Nano, Maddalena, Letort, Gaëlle, Gemble, Simon, Edwards, Frances, Goundiam, Oumou, Gogendeau, Delphine, Pennetier, Carole, Basto, Renata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7147111/
https://www.ncbi.nlm.nih.gov/pubmed/32328633
http://dx.doi.org/10.1083/jcb.201908006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7147111/
https://www.ncbi.nlm.nih.gov/pubmed/32328633
http://dx.doi.org/10.1083/jcb.201908006

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