Long non-coding RNA HOTAIR drives EZH2-dependent myofibroblast activation in systemic sclerosis through miRNA 34a-dependent activation of NOTCH

BACKGROUND: Systemic sclerosis (SSc) is characterised by autoimmune activation, tissue and vascular fibrosis in the skin and internal organs. Tissue fibrosis is driven by myofibroblasts, that are known to maintain their phenotype in vitro, which is associated with epigenetically driven trimethylatio...

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Detalles Bibliográficos
Autores principales: Wasson, Christopher W, Abignano, Giuseppina, Hermes, Heidi, Malaab, Maya, Ross, Rebecca L, Jimenez, Sergio A, Chang, Howard Y, Feghali-Bostwick, Carol A, del Galdo, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Systemic Sclerosis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7147169/
https://www.ncbi.nlm.nih.gov/pubmed/32041748
http://dx.doi.org/10.1136/annrheumdis-2019-216542

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7147169/
https://www.ncbi.nlm.nih.gov/pubmed/32041748
http://dx.doi.org/10.1136/annrheumdis-2019-216542

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