Cargando…

Neutrophil L-Plastin Controls Ocular Paucibacteriality and Susceptibility to Keratitis

Why ocular mucosa is paucibacterial is unknown. Many different mechanisms have been suggested but the comprehensive experimental studies are sparse. We found that a deficiency in L-plastin (LCP1), an actin bundling protein, resulted in an ocular commensal overgrowth, characterized with increased pre...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lu, Xiaoxiao, Kugadas, Abirami, Smith-Page, Kirsten, Lamb, Jeffrey, Lin, Tiffany, Ru, Yusha, Morley, Sharon Celeste, Fichorova, Raina, Mittal, Sharad K., Chauhan, Sunil K., Littleton, Sejiro, Saban, Daniel, Gadjeva, Mihaela
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7147296/ https://www.ncbi.nlm.nih.gov/pubmed/32318063 http://dx.doi.org/10.3389/fimmu.2020.00547

Ejemplares similares

Impact of Microbiota on Resistance to Ocular Pseudomonas aeruginosa-Induced Keratitis
por: Kugadas, Abirami, et al.
Publicado: (2016)

Tasked with a Challenging Objective: Why Do Neutrophils Fail to Battle Pseudomonas aeruginosa Biofilms
por: Geddes-McAlister, Jennifer, et al.
Publicado: (2019)

Prenylcysteine oxidase 1 like protein is required for neutrophil bactericidal activities
por: Petenkova, Anastasiia, et al.
Publicado: (2023)

Role of Microbiota in Strengthening Ocular Mucosal Barrier Function Through Secretory IgA
por: Kugadas, Abirami, et al.
Publicado: (2017)

Paucibacterial Microbiome and Resident DNA Virome of the Healthy Conjunctiva
por: Doan, Thuy, et al.
Publicado: (2016)

Efficient T Cell Migration and Activation Require L-Plastin
por: Joshi, Hemant, et al.
Publicado: (2022)

Expression of non-phosphorylatable S5A-L-plastin exerts phenotypes distinct from L-plastin deficiency during podosome formation and phagocytosis
por: Lin, Xue, et al.
Publicado: (2023)

The Actin-Bundling Protein L-Plastin: A Critical Regulator of Immune Cell Function
por: Morley, Sharon Celeste
Publicado: (2012)

CD74 deficiency ameliorates Pseudomonas aeruginosa-induced ocular infection
por: Zaidi, Tanweer, et al.
Publicado: (2011)

Frontline Science: Employing enzymatic treatment options for management of ocular biofilm‐based infections
por: Kugadas, Abirami, et al.
Publicado: (2019)

The NLRP3 Inflammasome Is Required for Protection Against Pseudomonas Keratitis
por: Ramadan, Abdulraouf, et al.
Publicado: (2023)

Inhibition of Macrophage Migration Inhibitory Factor Ameliorates Ocular Pseudomonas aeruginosa-Induced Keratitis
por: Gadjeva, Mihaela, et al.
Publicado: (2010)

LRRK1 regulation of actin assembly in osteoclasts involves serine 5 phosphorylation of L‐plastin
por: Si, Mingjue, et al.
Publicado: (2018)

Matrigel induces L-plastin expression and promotes L-plastin-dependent invasion in human cholangiocarcinoma cells
por: CHAIJAN, SUTHIDARAK, et al.
Publicado: (2014)

Plastination: ethical and medico-legal considerations
por: Bin, Paola, et al.
Publicado: (2016)

Editorial: The use of large animal models to improve pre-clinical translational research
por: Gray, Mark, et al.
Publicado: (2022)

Functional differences between L- and T-plastin isoforms
Publicado: (1994)

Dry preservation of Toxocara vitulorum by plastination technique
por: Kumar, Niranjan, et al.
Publicado: (2019)

The Interspinous Spacer: A Clinicoanatomical Investigation Using Plastination
por: Kaulhausen, Thomas, et al.
Publicado: (2012)

Plastination of decalcified bone by a new resin technique
por: Rabiei, Abbas Ali, et al.
Publicado: (2014)

Plastin 3 in health and disease: a matter of balance
por: Wolff, Lisa, et al.
Publicado: (2021)

Structural mechanism for bidirectional actin cross-linking by T-plastin
por: Mei, Lin, et al.
Publicado: (2022)

Is domestic polyester suitable for plastination of thin brain slices?
por: Juvenato, L.S., et al.
Publicado: (2023)

L-plastin enhances NLRP3 inflammasome assembly and bleomycin-induced lung fibrosis
por: Joshi, Hemant, et al.
Publicado: (2022)

Clinical differentiation of Pythium keratitis from fungal keratitis and development of a scoring system
por: Chatterjee, Samrat, et al.
Publicado: (2022)

Looking into nerve damage in the cornea
por: Gadjeva, Mihaela
Publicado: (2019)

Plastination: A novel, innovative teaching adjunct in oral pathology
por: Ravi, Spoorthi Banavar, et al.
Publicado: (2011)

Plastination of macroparasites: An eco-friendly method of long-term preservation
por: Kumar, Niranjan, et al.
Publicado: (2017)

Plastin and spectrin cooperate to stabilize the actomyosin cortex during cytokinesis
por: Sobral, Ana Filipa, et al.
Publicado: (2021)

Plastination with low viscosity silicone: strategy for less tissue shrinkage
por: Monteiro, Y.F., et al.
Publicado: (2022)

L-Plastin deficiency produces increased trabecular bone due to attenuation of sealing ring formation and osteoclast dysfunction
por: Chellaiah, Meenakshi A., et al.
Publicado: (2020)

T-Plastin Expression Downstream to the Calcineurin/NFAT Pathway Is Involved in Keratinocyte Migration
por: Brun, Cécilia, et al.
Publicado: (2014)

The Calcium-Dependent Switch Helix of L-Plastin Regulates Actin Bundling
por: Ishida, Hiroaki, et al.
Publicado: (2017)

Plastin increases cortical connectivity to facilitate robust polarization and timely cytokinesis
por: Ding, Wei Yung, et al.
Publicado: (2017)

An improved plastination method for strengthening bamboo culms, without compromising biodegradability
por: Osmond, Reeghan, et al.
Publicado: (2023)

Does NETosis Contribute to the Bacterial Pathoadaptation in Cystic Fibrosis?
por: Rahman, Samir, et al.
Publicado: (2014)

Targeted deletion of the zebrafish actin-bundling protein L-plastin (lcp1)
por: Kell, Margaret J., et al.
Publicado: (2018)

Plastin3 is associated with epithelial-mesenchymal transition and poor prognosis in gastric cancer
por: Kurashige, Junji, et al.
Publicado: (2019)

T-Plastin reinforces membrane protrusions to bridge matrix gaps during cell migration
por: Garbett, Damien, et al.
Publicado: (2020)

Targeting actin-bundling protein L-plastin as an anabolic therapy for bone loss
por: Li, Xiaoqun, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_j6qp53c4k7stpu7imumhe3roqp