Investigation of meropenem stability after reconstitution: the influence of buffering and challenges to meet the NHS Yellow Cover Document compliance for continuous infusions in an outpatient setting

OBJECTIVES: To determine the influence of different buffers, pH and meropenem concentrations on the degradation rates of meropenem in aqueous solution during storage at 32°C, with the aim of developing a formulation suitable for 24-hour infusion in an ambulatory elastomeric device, compliant with th...

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Detalles Bibliográficos
Autores principales: Jamieson, Conor, Allwood, Michael Charles, Stonkute, Donata, Wallace, Andrew, Wilkinson, Alan-Shaun, Hills, Tim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7147560/
https://www.ncbi.nlm.nih.gov/pubmed/32296506
http://dx.doi.org/10.1136/ejhpharm-2018-001699

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7147560/
https://www.ncbi.nlm.nih.gov/pubmed/32296506
http://dx.doi.org/10.1136/ejhpharm-2018-001699

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