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Cell type-specific drug-inducible protein synthesis inhibition demonstrates that memory consolidation requires rapid neuronal translation

New protein synthesis is known to be required for the consolidation of memories, yet existing methods to block translation lack spatiotemporal precision and cell-type specificity, preventing investigation of cell-specific contributions of protein synthesis. Here, we developed a combined knock-in mou...

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Detalles Bibliográficos
Autores principales: Shrestha, Prerana, Ayata, Pinar, Herrero-Vidal, Pedro, Longo, Francesco, Gastone, Alexandra, Ledoux, Joseph E., Heintz, Nathaniel, Klann, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7147976/
https://www.ncbi.nlm.nih.gov/pubmed/31959934
http://dx.doi.org/10.1038/s41593-019-0568-z