microRNA overexpression in slow transit constipation leads to reduced Na(V)1.5 current and altered smooth muscle contractility

OBJECTIVE: This study was designed to evaluate the roles of microRNAs (miRNAs) in slow transit constipation (STC). DESIGN: All human tissue samples were from the muscularis externa of the colon. Expression of 372 miRNAs was examined in a discovery cohort of four patients with STC versus three age/se...

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Detalles Bibliográficos
Autores principales: Mazzone, Amelia, Strege, Peter R, Gibbons, Simon J, Alcaino, Constanza, Joshi, Vikram, Haak, Andrew J, Tschumperlin, Daniel J, Bernard, Cheryl E, Cima, Robert R, Larson, David W, Chua, Heidi K, Graham, Rondell P, El Refaey, Mona, Mohler, Peter J, Hayashi, Yujiro, Ordog, Tamas, Calder, Stefan, Du, Peng, Farrugia, Gianrico, Beyder, Arthur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Neurogastroenterology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7147984/
https://www.ncbi.nlm.nih.gov/pubmed/31757880
http://dx.doi.org/10.1136/gutjnl-2019-318747

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7147984/
https://www.ncbi.nlm.nih.gov/pubmed/31757880
http://dx.doi.org/10.1136/gutjnl-2019-318747

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