Histone deacetylases 1 and 2 silence cryptic transcription to promote mitochondrial function during cardiogenesis

Cryptic transcription occurs widely across the eukaryotic genome; however, its regulation during vertebrate development is not understood. Here, we show that two class I histone deacetylases, Hdac1 and Hdac2, silence cryptic transcription to promote mitochondrial function in developing murine hearts...

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Detalles Bibliográficos
Autores principales: Milstone, Zachary J., Saheera, Sherin, Bourke, Lauren M., Shpilka, Tomer, Haynes, Cole M., Trivedi, Chinmay M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7148095/
https://www.ncbi.nlm.nih.gov/pubmed/32300642
http://dx.doi.org/10.1126/sciadv.aax5150

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7148095/
https://www.ncbi.nlm.nih.gov/pubmed/32300642
http://dx.doi.org/10.1126/sciadv.aax5150

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