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Histone deacetylases 1 and 2 silence cryptic transcription to promote mitochondrial function during cardiogenesis
Cryptic transcription occurs widely across the eukaryotic genome; however, its regulation during vertebrate development is not understood. Here, we show that two class I histone deacetylases, Hdac1 and Hdac2, silence cryptic transcription to promote mitochondrial function in developing murine hearts...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Association for the Advancement of Science
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7148095/ https://www.ncbi.nlm.nih.gov/pubmed/32300642 http://dx.doi.org/10.1126/sciadv.aax5150 |