Molecular mechanism of the dual regulatory roles of ATP on the αγ heterodimer of human NAD-dependent isocitrate dehydrogenase

Human NAD-dependent isocitrate dehydrogenase (NAD-IDH) is responsible for the catalytic conversion of isocitrate into α-ketoglutarate in the Krebs cycle. This enzyme exists as the α(2)βγ heterotetramer composed of the αβ and αγ heterodimers. Our previous biochemical data showed that the αγ heterodim...

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Detalles Bibliográficos
Autores principales: Sun, Pengkai, Bai, Tuya, Ma, Tengfei, Ding, Jianping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7148312/
https://www.ncbi.nlm.nih.gov/pubmed/32277159
http://dx.doi.org/10.1038/s41598-020-63425-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7148312/
https://www.ncbi.nlm.nih.gov/pubmed/32277159
http://dx.doi.org/10.1038/s41598-020-63425-6

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