A Two-Component regulatory system with opposite effects on glycopeptide antibiotic biosynthesis and resistance

The glycopeptide A40926, produced by the actinomycete Nonomuraea gerenzanensis, is the precursor of dalbavancin, a second-generation glycopeptide antibiotic approved for clinical use in the USA and Europe in 2014 and 2015, respectively. The final product of the biosynthetic pathway is an O-acetylate...

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Detalles Bibliográficos
Autores principales: Alduina, Rosa, Tocchetti, Arianna, Costa, Salvatore, Ferraro, Clelia, Cancemi, Patrizia, Sosio, Margherita, Donadio, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7148328/
https://www.ncbi.nlm.nih.gov/pubmed/32277112
http://dx.doi.org/10.1038/s41598-020-63257-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7148328/
https://www.ncbi.nlm.nih.gov/pubmed/32277112
http://dx.doi.org/10.1038/s41598-020-63257-4

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