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Directed evolution of a transcription factor PbrR to improve lead selectivity and reduce zinc interference through dual selection
Directed evolution has been proven as a powerful tool for developing proteins and strains with novel or enhanced features. In this study, a dual selection system was designed to tune the binding specificity of a transcription factor to a particular ligand with the ampicillin resistance gene amp (ON...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer Berlin Heidelberg
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7148400/ https://www.ncbi.nlm.nih.gov/pubmed/32277291 http://dx.doi.org/10.1186/s13568-020-01004-8 |