Amyloid β chaperone — lipocalin-type prostaglandin D synthase acts as a peroxidase in the presence of heme

The extracellular transporter, lipocalin-type prostaglandin D synthase (L-PGDS) binds to heme and heme metabolites with high affinity. It has been reported that L-PGDS protects neuronal cells against apoptosis induced by exposure to hydrogen peroxide. Our study demonstrates that when human WT L-PGDS...

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Detalles Bibliográficos
Autores principales: Phillips, Margaret, Kannaian, Bhuvaneswari, Yang, Justin Ng Tze, Kather, Ralf, Yuguang, Mu, Harmer, Jeffrey R., Pervushin, Konstantin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2020
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7148433/
https://www.ncbi.nlm.nih.gov/pubmed/32271881
http://dx.doi.org/10.1042/BCJ20190536

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7148433/
https://www.ncbi.nlm.nih.gov/pubmed/32271881
http://dx.doi.org/10.1042/BCJ20190536

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