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A combination of two human monoclonal antibodies limits fetal damage by Zika virus in macaques

Human infection by Zika virus (ZIKV) during pregnancy can lead to vertical transmission and fetal aberrations, including microcephaly. Prophylactic administration of antibodies can diminish or prevent ZIKV infection in animal models, but whether passive immunization can protect nonhuman primates and...

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Detalles Bibliográficos
Autores principales: Van Rompay, Koen K. A., Coffey, Lark L., Kapoor, Tania, Gazumyan, Anna, Keesler, Rebekah I., Jurado, Andrea, Peace, Avery, Agudelo, Marianna, Watanabe, Jennifer, Usachenko, Jodie, Singapuri, Anil, Immareddy, Ramya, Ardeshir, Amir, Stuart, Jackson B., Bournazos, Stylianos, Ravetch, Jeffrey V., Balderes, Paul J., Lorenz, Ivo C., Esswein, Shannon R., Keeffe, Jennifer R., Bjorkman, Pamela J., Wang, Qiao, Rice, Charles M., MacDonald, Margaret R., Nussenzweig, Michel C., Robbiani, Davide F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7149495/
https://www.ncbi.nlm.nih.gov/pubmed/32209664
http://dx.doi.org/10.1073/pnas.2000414117