The cholesterol 24-hydroxylase activates autophagy and decreases mutant huntingtin build-up in a neuroblastoma culture model of Huntington’s disease

OBJECTIVE: Compromised brain cholesterol turnover and altered regulation of brain cholesterol metabolism have been allied with some neurodegenerative diseases, including Huntington’s disease (HD). Following our previous studies in HD, in this study we aim to investigate in vitro in a neuroblastoma c...

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Detalles Bibliográficos
Autores principales: Nóbrega, Clévio, Conceição, André, Costa, Rafael G., Koppenol, Rebekah, Sequeira, Raquel L., Nunes, Ricardo, Carmo-Silva, Sara, Marcelo, Adriana, Matos, Carlos A., Betuing, Sandrine, Caboche, Jocelyne, Cartier, Nathalie, Alves, Sandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7149904/
https://www.ncbi.nlm.nih.gov/pubmed/32276655
http://dx.doi.org/10.1186/s13104-020-05053-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7149904/
https://www.ncbi.nlm.nih.gov/pubmed/32276655
http://dx.doi.org/10.1186/s13104-020-05053-x

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