Metformin rescues rapamycin-induced mitochondrial dysfunction and attenuates rheumatoid arthritis with metabolic syndrome

BACKGROUND: Rapamycin, an inhibitor of the serine/threonine protein kinase mTOR, is an immunosuppressant used to treat renal transplant recipients, but it can cause endothelial and mitochondrial dysfunction. Metformin is used for the treatment of type 2 diabetes and was reported to exert therapeutic...

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Detalles Bibliográficos
Autores principales: Kim, Eun Kyung, Min, Hong Ki, Lee, Seon-Yeong, Kim, Da-Som, Ryu, Jun-Geol, Na, Hyun Sik, Jung, Kyoung Ah, Choi, Jeong Won, Park, Sung-Hwan, Cho, Mi-La
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7149912/
https://www.ncbi.nlm.nih.gov/pubmed/32276645
http://dx.doi.org/10.1186/s13075-020-02174-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7149912/
https://www.ncbi.nlm.nih.gov/pubmed/32276645
http://dx.doi.org/10.1186/s13075-020-02174-3

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