Advances in CRISPR/Cas-based Gene Therapy in Human Genetic Diseases

CRISPR/Cas genome editing is a simple, cost effective, and highly specific technique for introducing genetic variations. In mammalian cells, CRISPR/Cas can facilitate non-homologous end joining, homology- directed repair, and single-base exchanges. Cas9/Cas12a nuclease, dCas9 transcriptional regulat...

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Detalles Bibliográficos
Autores principales: Wu, Shao-Shuai, Li, Qing-Cui, Yin, Chang-Qing, Xue, Wen, Song, Chun-Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7150498/
https://www.ncbi.nlm.nih.gov/pubmed/32292501
http://dx.doi.org/10.7150/thno.43360

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7150498/
https://www.ncbi.nlm.nih.gov/pubmed/32292501
http://dx.doi.org/10.7150/thno.43360

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