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Cytoplasmic Autoinhibition in HCN Channels is Regulated by the Transmembrane Region

Hyperpolarization-activated cation-nonselective (HCN) channels regulate electrical activity in the brain and heart in a cAMP-dependent manner. The voltage-gating of these channels is mediated by a transmembrane (TM) region but is additionally regulated by direct binding of cAMP to a cyclic nucleotid...

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Detalles Bibliográficos
Autores principales: Page, Dana A., Magee, Kaylee E. A., Li, Jessica, Jung, Matthew, Young, Edgar C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7150657/
https://www.ncbi.nlm.nih.gov/pubmed/32146488
http://dx.doi.org/10.1007/s00232-020-00111-8