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Cytoplasmic Autoinhibition in HCN Channels is Regulated by the Transmembrane Region
Hyperpolarization-activated cation-nonselective (HCN) channels regulate electrical activity in the brain and heart in a cAMP-dependent manner. The voltage-gating of these channels is mediated by a transmembrane (TM) region but is additionally regulated by direct binding of cAMP to a cyclic nucleotid...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer US
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7150657/ https://www.ncbi.nlm.nih.gov/pubmed/32146488 http://dx.doi.org/10.1007/s00232-020-00111-8 |