CRISPR-Cas9 Dual-gRNA Attack Causes Mutation, Excision and Inversion of the HIV-1 Proviral DNA

Although several studies demonstrated that the HIV proviral DNA can be effectively targeted and inactivated by the CRISPR-Cas9 system, the precise inactivation mechanism has not yet been analyzed. Whereas some studies suggested efficient proviral DNA excision upon dual-gRNA/Cas9 treatment, we previo...

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Detalles Bibliográficos
Autores principales: Binda, Caroline S., Klaver, Bep, Berkhout, Ben, Das, Atze T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7150824/
https://www.ncbi.nlm.nih.gov/pubmed/32197474
http://dx.doi.org/10.3390/v12030330

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7150824/
https://www.ncbi.nlm.nih.gov/pubmed/32197474
http://dx.doi.org/10.3390/v12030330

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