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CRISPR-Cas9 Dual-gRNA Attack Causes Mutation, Excision and Inversion of the HIV-1 Proviral DNA

Although several studies demonstrated that the HIV proviral DNA can be effectively targeted and inactivated by the CRISPR-Cas9 system, the precise inactivation mechanism has not yet been analyzed. Whereas some studies suggested efficient proviral DNA excision upon dual-gRNA/Cas9 treatment, we previo...

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Detalles Bibliográficos
Autores principales:	Binda, Caroline S., Klaver, Bep, Berkhout, Ben, Das, Atze T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7150824/ https://www.ncbi.nlm.nih.gov/pubmed/32197474 http://dx.doi.org/10.3390/v12030330

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