Improved Stability of Rifampicin in the Presence of Gastric-Resistant Isoniazid Microspheres in Acidic Media

The degradation of rifampicin (RIF) in an acidic medium to form 3-formyl rifamycin SV, a poorly absorbed compound, is accelerated in the presence of isoniazid, contributing to the poor bioavailability of rifampicin. This manuscript presents a novel approach in which isoniazid is formulated into gast...

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Detalles Bibliográficos
Autores principales: Mwila, Chiluba, Walker, Roderick B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7150845/
https://www.ncbi.nlm.nih.gov/pubmed/32151053
http://dx.doi.org/10.3390/pharmaceutics12030234

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7150845/
https://www.ncbi.nlm.nih.gov/pubmed/32151053
http://dx.doi.org/10.3390/pharmaceutics12030234

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