Cargando…

Regional Intestinal Drug Permeability and Effects of Permeation Enhancers in Rat

Sufficient colonic absorption is necessary for all systemically acting drugs in dosage forms that release the drug in the large intestine. Preclinically, colonic absorption is often investigated using the rat single-pass intestinal perfusion model. This model can determine intestinal permeability ba...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dahlgren, David, Cano-Cebrián, Maria-Jose, Olander, Tobias, Hedeland, Mikael, Sjöblom, Markus, Lennernäs, Hans
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7150977/ https://www.ncbi.nlm.nih.gov/pubmed/32182653 http://dx.doi.org/10.3390/pharmaceutics12030242

Ejemplares similares

Effect of paracellular permeation enhancers on intestinal permeability of two peptide drugs, enalaprilat and hexarelin, in rats
por: Dahlgren, David, et al.
Publicado: (2021)

The In Vivo Effect of Transcellular Permeation Enhancers on the Intestinal Permeability of Two Peptide Drugs Enalaprilat and Hexarelin
por: Dahlgren, David, et al.
Publicado: (2020)

Chemotherapeutics Combined with Luminal Irritants: Effects on Small-Intestinal Mannitol Permeability and Villus Length in Rats
por: Cano-Cebrián, Maria-José, et al.
Publicado: (2022)

Prevention of Rat Intestinal Injury with a Drug Combination of Melatonin and Misoprostol
por: Dahlgren, David, et al.
Publicado: (2020)

Protective Effects of Melatonin and Misoprostol against Experimentally Induced Increases in Intestinal Permeability in Rats
por: Peters, Karsten, et al.
Publicado: (2022)

Melatonin-Activated Receptor Signaling Pathways Mediate Protective Effects on Surfactant-Induced Increase in Jejunal Mucosal Permeability in Rats
por: Peters, Karsten, et al.
Publicado: (2021)

Intestinal Permeability and Drug Absorption: Predictive Experimental, Computational and In Vivo Approaches
por: Dahlgren, David, et al.
Publicado: (2019)

Chemotherapeutics-Induced Intestinal Mucositis: Pathophysiology and Potential Treatment Strategies
por: Dahlgren, David, et al.
Publicado: (2021)

Hypotonicity-Induced Increase in Duodenal Mucosal Permeability Is Regulated by Cholinergic Receptors in Rats
por: Dahlgren, David, et al.
Publicado: (2022)

Orthogonality in Principal Component Analysis Allows the Discovery of Lipids in the Jejunum That Are Independent of Ad Libitum Feeding
por: Balgoma, David, et al.
Publicado: (2022)

Intestinal absorption of BCS class II drugs administered as nanoparticles: A review based on in vivo data from intestinal perfusion models
por: Dahlgren, David, et al.
Publicado: (2020)

Evaluation and validation of chemotherapy‐specific diarrhoea and histopathology in rats
por: Dahlgren, David, et al.
Publicado: (2022)

The progression of doxorubicin-induced intestinal mucositis in rats
por: Kullenberg, F., et al.
Publicado: (2022)

Antibody-Drug Conjugates and Targeted Treatment Strategies for Hepatocellular Carcinoma: A Drug-Delivery Perspective
por: Dahlgren, David, et al.
Publicado: (2020)

The Impact of α-Adrenoceptors in the Regulation of the Hypotonicity-Induced Increase in Duodenal Mucosal Permeability In Vivo
por: Sedin, John, et al.
Publicado: (2021)

Utilization of Sodium Nitroprusside as an Intestinal Permeation Enhancer for Lipophilic Drug Absorption Improvement in the Rat Proximal Intestine
por: Kishimoto, Hisanao, et al.
Publicado: (2021)

Openable artificial intestinal tract device integrated with a permeable filter for evaluating drug permeation through cells
por: Konishi, Satoshi, et al.
Publicado: (2023)

Anthracyclins Increase PUFAs: Potential Implications in ER Stress and Cell Death
por: Balgoma, David, et al.
Publicado: (2021)

Zonulin Regulates Intestinal Permeability and Facilitates Enteric Bacteria Permeation in Coronary Artery Disease
por: Li, Chuanwei, et al.
Publicado: (2016)

Validation of an Ex Vivo Permeation Method for the Intestinal Permeability of Different BCS Drugs and Its Correlation with Caco-2 In Vitro Experiments
por: B. Sánchez, Aroha, et al.
Publicado: (2019)

Impact of Intestinal Concentration and Colloidal Structure on the Permeation-Enhancing Efficiency of Sodium Caprate in the Rat
por: Berg, Staffan, et al.
Publicado: (2021)

Enhanced Intestinal Permeation of Doxorubicin Using Chitosan Nanoparticles
por: Zare, Marziyeh, et al.
Publicado: (2018)

Effects of α(2)-adrenoceptor stimulation on luminal alkalinisation and net fluid flux in rat duodenum
por: Nylander, Olof, et al.
Publicado: (2022)

Effect of Chemical Permeation Enhancers on Skin Permeability: In silico screening using Molecular Dynamics simulations
por: Gupta, Rakesh, et al.
Publicado: (2019)

In Vitro Cell Toxicity and Intracellular Uptake of Doxorubicin Exposed as a Solution or Liposomes: Implications for Treatment of Hepatocellular Carcinoma
por: Kullenberg, Fredrik, et al.
Publicado: (2021)

Human small intestinal organotypic culture model for drug permeation, inflammation, and toxicity assays
por: Markus, Jan, et al.
Publicado: (2020)

Oleacein Intestinal Permeation and Metabolism in Rats Using an In Situ Perfusion Technique
por: López-Yerena, Anallely, et al.
Publicado: (2021)

Drug Absorption Parameters Obtained Using the Isolated Perfused Rat Lung Model Are Predictive of Rat In Vivo Lung Absorption
por: Eriksson, Johanna, et al.
Publicado: (2020)

An Enteric-Coated Polyelectrolyte Nanocomplex Delivers Insulin in Rat Intestinal Instillations When Combined with a Permeation Enhancer
por: Sladek, Svenja, et al.
Publicado: (2020)

Optimization of a Self-microemulsifying Drug Delivery System for Oral Administration of the Lipophilic Drug, Resveratrol: Enhanced Intestinal Permeability in Rat
por: Mirzaeei, Shahla, et al.
Publicado: (2023)

Recent Patents on Permeation Enhancers for Drug Delivery Through Nails
por: Kreutz, Tainá, et al.
Publicado: (2019)

Mechanisms and Extent of Enhanced Passive Permeation by Colloidal Drug Particles
por: Narula, Akshay, et al.
Publicado: (2022)

A Model for Calcium Permeation into Small Intestine
por: Dolinska, Barbara, et al.
Publicado: (2010)

Self-Microemulsifying Drug Delivery System: Formulation and Study Intestinal Permeability of Ibuprofen in Rats
por: Subudhi, Bharat Bhushan, et al.
Publicado: (2013)

Enhanced Permeation of an Antiemetic Drug from Buccoadhesive Tablets by Using Bile Salts as Permeation Enhancers: Formulation Characterization, In Vitro, and Ex Vivo Studies
por: Jain, C. P., et al.
Publicado: (2016)

Evaluation of Sucrose Laurate as an Intestinal Permeation Enhancer for Macromolecules: Ex Vivo and In Vivo Studies
por: McCartney, Fiona, et al.
Publicado: (2019)

Long‐term daily oral administration of intestinal permeation enhancers is safe and effective in mice
por: Fein, Katherine C., et al.
Publicado: (2022)

Unroasted Green Coffee Extract-Loaded Solid Lipid Nanoparticles for Enhancing Intestinal Permeation
por: Moussa, Yomna A., et al.
Publicado: (2023)

BCS Class IV Oral Drugs and Absorption Windows: Regional-Dependent Intestinal Permeability of Furosemide
por: Markovic, Milica, et al.
Publicado: (2020)

Study protocol for locoregional precision treatment of hepatocellular carcinoma with transarterial chemoembolisation (TACTida), a clinical study: idarubicin dose selection, tissue response and survival
por: Nyman, Sofi Sennefelt, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_qfdgo5dkhu8lrgdiknlrghrjdg