Novel Carboxylated Chitosan-Based Triptolide Conjugate for the Treatment of Rheumatoid Arthritis

A new platform for triptolide (TP) delivery was prepared by conjugating TP to a carboxylmethyl chitosan (CMCS). Compared with the natural TP, the TP-conjugate (TP-CMCS) containing TP of ~5 wt% exhibited excellent aqueous solubility (>5 mg/mL). Results of in vitro experiments showed that TP-CMCS c...

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Detalles Bibliográficos
Autores principales: Zhang, Lan, Yan, Min, Chen, Kun, Tian, Qikang, Song, Junying, Zhang, Zijuan, Xie, Zhishen, Yuan, Yong, Jia, Yaquan, Zhu, Xin, Zhang, Zhenqiang, Wu, Xiangxiang, Zeng, Huahui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7150988/
https://www.ncbi.nlm.nih.gov/pubmed/32110979
http://dx.doi.org/10.3390/pharmaceutics12030202

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7150988/
https://www.ncbi.nlm.nih.gov/pubmed/32110979
http://dx.doi.org/10.3390/pharmaceutics12030202

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