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Novel Carboxylated Chitosan-Based Triptolide Conjugate for the Treatment of Rheumatoid Arthritis

A new platform for triptolide (TP) delivery was prepared by conjugating TP to a carboxylmethyl chitosan (CMCS). Compared with the natural TP, the TP-conjugate (TP-CMCS) containing TP of ~5 wt% exhibited excellent aqueous solubility (>5 mg/mL). Results of in vitro experiments showed that TP-CMCS c...

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Detalles Bibliográficos
Autores principales:	Zhang, Lan, Yan, Min, Chen, Kun, Tian, Qikang, Song, Junying, Zhang, Zijuan, Xie, Zhishen, Yuan, Yong, Jia, Yaquan, Zhu, Xin, Zhang, Zhenqiang, Wu, Xiangxiang, Zeng, Huahui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7150988/ https://www.ncbi.nlm.nih.gov/pubmed/32110979 http://dx.doi.org/10.3390/pharmaceutics12030202

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