An Enteric-Coated Polyelectrolyte Nanocomplex Delivers Insulin in Rat Intestinal Instillations When Combined with a Permeation Enhancer

The use of nanocarriers is being researched to achieve oral peptide delivery. Insulin-associated anionic polyelectrolyte nanoparticle complexes (PECs) were formed that comprised hyaluronic acid and chitosan in an optimum mass mixing ratio of 5:1 (MR 5), followed by coating with a pH-dependent polyme...

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Detalles Bibliográficos
Autores principales: Sladek, Svenja, McCartney, Fiona, Eskander, Mena, Dunne, David J., Santos-Martinez, Maria Jose, Benetti, Federico, Tajber, Lidia, Brayden, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7151133/
https://www.ncbi.nlm.nih.gov/pubmed/32178442
http://dx.doi.org/10.3390/pharmaceutics12030259

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7151133/
https://www.ncbi.nlm.nih.gov/pubmed/32178442
http://dx.doi.org/10.3390/pharmaceutics12030259

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