Bioisosteric Replacement as a Tool in Anti-HIV Drug Design

Bioisosteric replacement is a powerful tool for modulating the drug-like properties, toxicity, and chemical space of experimental therapeutics. In this review, we focus on selected cases where bioisosteric replacement and scaffold hopping have been used in the development of new anti-HIV-1 therapeut...

Descripción completa

Detalles Bibliográficos
Autores principales: Dick, Alexej, Cocklin, Simon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7151723/
https://www.ncbi.nlm.nih.gov/pubmed/32121077
http://dx.doi.org/10.3390/ph13030036
_version_ 1783521315542532096
author Dick, Alexej
Cocklin, Simon
author_facet Dick, Alexej
Cocklin, Simon
author_sort Dick, Alexej
collection PubMed
description Bioisosteric replacement is a powerful tool for modulating the drug-like properties, toxicity, and chemical space of experimental therapeutics. In this review, we focus on selected cases where bioisosteric replacement and scaffold hopping have been used in the development of new anti-HIV-1 therapeutics. Moreover, we cover field-based, computational methodologies for bioisosteric replacement, using studies from our group as an example. It is our hope that this review will serve to highlight the utility and potential of bioisosteric replacement in the continuing search for new and improved anti-HIV drugs.
format Online
Article
Text
id pubmed-7151723
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-71517232020-04-20 Bioisosteric Replacement as a Tool in Anti-HIV Drug Design Dick, Alexej Cocklin, Simon Pharmaceuticals (Basel) Review Bioisosteric replacement is a powerful tool for modulating the drug-like properties, toxicity, and chemical space of experimental therapeutics. In this review, we focus on selected cases where bioisosteric replacement and scaffold hopping have been used in the development of new anti-HIV-1 therapeutics. Moreover, we cover field-based, computational methodologies for bioisosteric replacement, using studies from our group as an example. It is our hope that this review will serve to highlight the utility and potential of bioisosteric replacement in the continuing search for new and improved anti-HIV drugs. MDPI 2020-02-28 /pmc/articles/PMC7151723/ /pubmed/32121077 http://dx.doi.org/10.3390/ph13030036 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Dick, Alexej
Cocklin, Simon
Bioisosteric Replacement as a Tool in Anti-HIV Drug Design
title Bioisosteric Replacement as a Tool in Anti-HIV Drug Design
title_full Bioisosteric Replacement as a Tool in Anti-HIV Drug Design
title_fullStr Bioisosteric Replacement as a Tool in Anti-HIV Drug Design
title_full_unstemmed Bioisosteric Replacement as a Tool in Anti-HIV Drug Design
title_short Bioisosteric Replacement as a Tool in Anti-HIV Drug Design
title_sort bioisosteric replacement as a tool in anti-hiv drug design
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7151723/
https://www.ncbi.nlm.nih.gov/pubmed/32121077
http://dx.doi.org/10.3390/ph13030036
work_keys_str_mv AT dickalexej bioisostericreplacementasatoolinantihivdrugdesign
AT cocklinsimon bioisostericreplacementasatoolinantihivdrugdesign

Ejemplares similares