The impact of tunnel mutations on enzymatic catalysis depends on the tunnel-substrate complementarity and the rate-limiting step

Transport of ligands between bulk solvent and the buried active sites is a critical event in the catalytic cycle of many enzymes. The rational design of transport pathways is far from trivial due to the lack of knowledge about the effect of mutations on ligand transport. The main and an auxiliary tu...

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Detalles Bibliográficos
Autores principales: Kokkonen, Piia, Slanska, Michaela, Dockalova, Veronika, Pinto, Gaspar P., Sánchez-Carnerero, Esther M., Damborsky, Jiri, Klán, Petr, Prokop, Zbynek, Bednar, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7152659/
https://www.ncbi.nlm.nih.gov/pubmed/32308927
http://dx.doi.org/10.1016/j.csbj.2020.03.017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7152659/
https://www.ncbi.nlm.nih.gov/pubmed/32308927
http://dx.doi.org/10.1016/j.csbj.2020.03.017

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