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Quantifying nuclear wide chromatin compaction by phasor analysis of histone Förster resonance energy transfer (FRET) in frequency domain fluorescence lifetime imaging microscopy (FLIM) data
The nanometer spacing between nucleosomes throughout global chromatin organisation modulates local DNA template access, and through continuous dynamic rearrangements, regulates genome function [1]. However, given that nucleosome packaging occurs on a spatial scale well below the diffraction limit, r...
Autores principales: | Liang, Zhen, Lou, Jieqiong, Scipioni, Lorenzo, Gratton, Enrico, Hinde, Elizabeth |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7152662/ https://www.ncbi.nlm.nih.gov/pubmed/32300614 http://dx.doi.org/10.1016/j.dib.2020.105401 |
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