MutT homologue 1 (MTH1) removes N6-methyl-dATP from the dNTP pool

MutT homologue 1 (MTH1) removes oxidized nucleotides from the nucleotide pool and thereby prevents their incorporation into the genome and thereby reduces genotoxicity. We previously reported that MTH1 is an efficient catalyst of O6-methyl-dGTP hydrolysis suggesting that MTH1 may also sanitize the n...

Descripción completa

Detalles Bibliográficos
Autores principales: Scaletti, Emma Rose, Vallin, Karl S., Bräutigam, Lars, Sarno, Antonio, Warpman Berglund, Ulrika, Helleday, Thomas, Stenmark, Pål, Jemth, Ann-Sofie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2020
Materias:
Editors' Picks
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7152754/
https://www.ncbi.nlm.nih.gov/pubmed/32144205
http://dx.doi.org/10.1074/jbc.RA120.012636

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7152754/
https://www.ncbi.nlm.nih.gov/pubmed/32144205
http://dx.doi.org/10.1074/jbc.RA120.012636

Ejemplares similares