Exosomal communication by metastatic osteosarcoma cells modulates alveolar macrophages to an M2 tumor-promoting phenotype and inhibits tumoricidal functions

Osteosarcoma metastasizes to the lung, and there is a link between the predominance of tumor-promoting immunosuppressive M2 macrophages in the metastases and poor patient survival. By contrast, M1 macrophage predominance correlates with longer survival. M2 macrophages can be induced by various stimu...

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Detalles Bibliográficos
Autores principales: Wolf-Dennen, Kerri, Gordon, Nancy, Kleinerman, Eugenie S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7153823/
https://www.ncbi.nlm.nih.gov/pubmed/32313728
http://dx.doi.org/10.1080/2162402X.2020.1747677

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7153823/
https://www.ncbi.nlm.nih.gov/pubmed/32313728
http://dx.doi.org/10.1080/2162402X.2020.1747677

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