Pharmacokinetics and safety after once and twice a day doses of meclizine hydrochloride administered to children with achondroplasia

Achondroplasia (ACH) is the most common short-limbed skeletal dysplasia caused by activating mutations in the fibroblast growth factor receptor 3 (FGFR3) gene. We identified that meclizine hydrochloride inhibited FGFR3 signaling in various chondrocytic cells and promoted longitudinal bone growth in...

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Detalles Bibliográficos
Autores principales: Kitoh, Hiroshi, Matsushita, Masaki, Mishima, Kenichi, Nagata, Tadashi, Kamiya, Yasunari, Ueda, Kohei, Kuwatsuka, Yachiyo, Morikawa, Hiroshi, Nakai, Yasuhiro, Ishiguro, Naoki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7153885/
https://www.ncbi.nlm.nih.gov/pubmed/32282831
http://dx.doi.org/10.1371/journal.pone.0229639

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7153885/
https://www.ncbi.nlm.nih.gov/pubmed/32282831
http://dx.doi.org/10.1371/journal.pone.0229639

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